Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
Open Access
- 15 June 1993
- journal article
- Published by American Society of Hematology in Blood
- Vol. 81 (12) , 3234-3241
- https://doi.org/10.1182/blood.v81.12.3234.3234
Abstract
The expression of the hematopoietic transcription factors GATA-1, GATA- 2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.Keywords
This publication has 0 references indexed in Scilit: