Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures
Open Access
- 1 January 1996
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 17 (8) , 1633-1639
- https://doi.org/10.1093/carcin/17.8.1633
Abstract
There is accumulating evidence that cells exposed to low and often environmentally relevant doses of ionizing radiation survive the initial insult, but transmit genomic instability to their progeny. The underlying mechanism of radiationinduced genomic instability is unknown. We present biochemical evidence consistent with the hypothesis that enhanced and persistent oxy-radical activity may be responsible.Keywords
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