Suppression of Testicular Androgen Synthesis in the Rat by Ethylene Dimethanesulphonate
- 1 January 1971
- journal article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 2 (1-6) , 305-308
- https://doi.org/10.1159/000301872
Abstract
In the rat the antispermatogenic and anti-fertility effects of ethylene dimethanesulphonate (EDS) are associated with temporary involution of accessory glands. Using 4–14C-labelled progesterone it has been shown in vitro that marked and dose-dependent inhibition of testosterone synthesis occurred over a time range consistent with the duration of sterility. The results also indicated that the metabolism of pregnenolone and 17Α-hydroxyprogesterone are impaired.Keywords
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