DEATH FROM GRANULOCYTOPENIA AFTER SULFANILAMIDE THERAPY

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Abstract
Sulfanilamide is such a valuable drug that it is being used very widely and with perhaps some lack of caution. For this reason it seems wise to report another fatal case to the small series of severe granulocytopenias resulting presumably from its use. REPORT OF CASE Mrs. M. S., white, American, aged 22, entered the Riverside County Hospital Sept. 19, 1938, because of a severe throat infection of about two weeks' duration. There had been a high fever with vomiting for two days. At the time of entrance into the hospital there was no other relevant history. On physical examination at that time the patient was well developed and well nourished and appeared acutely ill. The temperature was 104.6 F., the pulse 136 and the respiratory rate 28. A general physical examination was done, examination of the vagina and rectum being omitted; the following observations were made: There were several

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