THE TREATMENT OF PREPUBERAL VULVOVAGINITIS WITH A NEW SYNTHETIC ESTROGEN

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Abstract
The first attempt to treat vulvovaginitis in infants and children with estrogenic biologic substance was in 1933, when Lewis1used it intramuscularly in eight cases. He succeeded in curing six cases. Subsequent attempts by others resulted in variable responses. Te Linde and Brawner2were successful in curing only one case in eleven, and Witherspoon3failed to obtain any successful result in ten cases. On the other hand, Goldberg, Minier and Smith4cured seven of nine cases and Limper and Hieronymus reported cures in twenty-four of their series of twenty-seven cases. All these investigators used the biologic estrogens intramuscularly and in suppositories, because attempts to administer them orally had been unsatisfactory. For example, Te Linde5used them orally in doses of from 3,000 to 16,000 international units for periods of from sixty-nine to 123 days without success. British physicians also used daily doses of from 3,000

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