Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (12) , 1289-1291
- https://doi.org/10.1093/carcin/2.12.1289
Abstract
Stable spontaneous mutants resistant to the protein synthesis inhibitor diphtheria toxin (DT) have been selected in human cell line EUE at a very low frequency (−6 ). U.v.-induced mutation has been quantitatively measured: treatment of cells with u.v. light increased the frequencies of diphtheria toxin resistant (DT r ) mutants up to 1000-fold. The maximum recovery of DT r mutants was observed after a short expression period, for all u.v. doses tested, and was followed by a decrease in mutation frequency on subsequent passages.Keywords
This publication has 3 references indexed in Scilit:
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- Isolation and characterization of mutants of human diploid fibroblasts resistant to diphtheria toxin.Proceedings of the National Academy of Sciences, 1978
- Selection and characterization of cells resistant to diphtheria toxin and pseudomonas exotoxin A: presumptive translational mutantsCell, 1977