SCID Continues to Point the Way

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Abstract
IN 1950 Glanzmann and Riniker described a new disease in two pairs of siblings and called it essentielle lymphocytophthise.1 These infants died of an intractable illness characterized by diarrhea, candidiasis, lymphopenia, and a striking diminution of lymphatic tissue. By the early 1960s more than 30 cases had been described, and the number of names for the disease almost equaled the number of cases.Over the past three decades this syndrome — now termed severe combined immunodeficiency, or SCID — has been recognized to include a spectrum of X-linked and autosomal genetic defects characterized by the inability to mount normal . . .