Response of experimental pain to analgesic drugs; III. Codeine, aspirin, secobarbital, and placebo

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Abstract
In previous studies16, 17 we demonstrated that the response to experimentally induced pain in man could be modified by morphine and codeine, but we were unable to show any significant effects of aspirin. In both studies, electrical stimulation of two fingers and ice‐water (cold‐pressor) stimulation of each hand were used to induce pain. Both techniques permit the direct observation of two pain response parameters, pain threshold (minimal pain) and pain tolerance (maximal stimulus intensity tolerated). A third parameter, pain sensitivity range (PSR), the difference between pain tolerance and pain threshold, can also be calculated.

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