PROPERDIN FACTOR-B (GLYCINE-RICH BETA-GLYCOPROTEIN OR C3 PROACTIVATOR)-POLYMORPHISM - GENETIC AND BIOCHEMICAL ASPECTS FIRST APPLICATION TO PATERNITY CASES

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  • 1 January 1975
    • journal article
    • research article
    • Vol. 150  (4) , 327-338
Abstract
Determination of genetic properdin factor B (Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after aging, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F, F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F 1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.

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