IMPAIRED PLATELET AGGREGATION AND INCREASED BLEEDING TIME DURING GENERAL ANAESTHESIA WITH HALOTHANE
- 1 October 1981
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 53 (10) , 1039-1042
- https://doi.org/10.1093/bja/53.10.1039
Abstract
A significant correlation was found between the inhibition produced by 1% halothane with nitrous oxide and oxygen on platelet aggregation in vitro and the increase in bleeding time during anaesthesia with halothane, nitrous oxide and oxygen in 10 patients. It is suggested that halothane in nitrous oxide with oxygen inhibits platelet aggregation in vivo and in vitro. The inhibition is not seen when platelet aggregation is studied in platelet-rich plasma from anaesthetized patients because the agents evaporate during preparation of platelet-rich plasma and during analysis in the aggregometer.Keywords
This publication has 0 references indexed in Scilit: