6-Acetylmethylenepenicillanic acid (Ro 15-1903), a potent .BETA.-lactamase inhibitor. I. Inhibition of chromosomally and R-factor-mediated .BETA.-lactamases.

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Abstract
6-Acetylmethylenepenicillanic acid (Ro 15-1903) is a powerful inhibitor of various [bacterial] .beta.-lactamases. Nearly all of the chromosomally and R-factor-mediated .beta.-lactamases which were studied were inhibited at much lower concentrations than required with clavulanic acid or sulbactam. Ro 15-1903 protected .beta.-lactamase-labile penicillins and cephalosporins from hydrolysis. The compound was stable against hydrolysis and inhibition of .beta.-lactamase was irreversible.