Quantitative Determination of Neuraminidase-Active Foci in Cell Monolayer Cultures Infected with Influenza or Newcastle Disease Virus

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Abstract
A synthetic neuraminidase substrate [2-(3′-methoxyphenyl)- N -acetyl-α-neuraminic acid] was used to detect myxo- and paramyxovirus replication in tissue culture. This method allowed estimation of viral growth even in the absence of cytopathogenic effects.