Induction of tumor suppression and delayed‐type footpad reaction by transfer of lymphocytes sensitized to a xenogenized tumor variant

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Abstract
Splenocytes immune to a highly immunogenic (“xenoge‐nized”, L5178Y/DTIC) variant of a murine lymphoma exert anti‐parental‐tumor activity in a systemic adoptive transfer system, the effect being apparently associated with the Lyt‐2− fraction of the lymphocyte population. During investigation of the mechanisms of this protection, we found that the L5178Y/DTIC tumor‐immune lymphocytes exhibited an appreciable anti‐L5178Y delayed‐type hypersensitivity (DTH) response. Enrichment of those lymphocytes in L3T4+ cells significantly enhanced the protective effect as well as the DTH reaction, whereas the use of an anti‐L3T4 but not anti‐Lyt‐2 reagent blocked both activities. In vitro, lymphocyte proliferation against L5178Y cells occurred and was apparently associated with the Lyt‐2− fraction of a population of L5178Y/DTIC immune splenocytes.