Alterations of Plasmin Activity, Plasminogen Levels and Activity of Antiplasmins during Endotoxin Shock in Dogs

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Abstract
Spontaneous plasmin activity and ‘fast-reacting’ and ‘time-dependent’ antiplasmin activities were determined during various stages of canine endotoxin shock by means of assays utilizing a chromogenic tripeptide derivative (S -2251, Kabi AB, Peptide Research Division, Mölndal). During shock, gradually decreasing values of both antiplasmins were found, revealing most pronounced falls of ‘fast-reacting’ antiplasmin. These changes of plasma antiplasmin activities were accompanied by decreasing values of plasminogen and evidence of plasmin activity. Immunochemical determination of plasma levels of α2-macro-globulin (α2-M) and α1-antitrypsin (α1-AT) and gel filtration studies, demonstrated marked falls in levels of α2-M and α2-plasmin inhibitor and small reductions of α1-AT in this state.

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