Chromosomal mapping of human creatine kinase (brain type) using human-rodent somatic cell hybrids
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 27 (4) , 232-237
- https://doi.org/10.1159/000131491
Abstract
Concordant segregation of human brain-type creatine kinase, CK(BB), expression with nucleoside phosphorylase (NP) expression and the presence of chromosome 14 was observed in 53 independently derived cell hybrids between CK(BB)-positive human cells and CK(BB)-negative rodent cells. Further analysis of 26 subclones of two CK(BB)-positive human-mouse cell hybrids confirmed the positive correlation of CK(BB) expression with NP expression. The results suggest that the gene coding for human CK(BB) can be assigned to chromosome 14.Keywords
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