THE EFFECT OF ADRENAL STEROIDS IN WATER INTOXICATION

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Abstract
When compared to a whole extract of the adrenal cortex, desoxycorticosterone acetate was relatively less effective in protection against excess water than in the maintenance of life and growth. Compound E was at least 3 times as efficient as desoxycorticosterone acetate in protecting against excess water. The amorphous fraction (Kendall) was only weakly effective in preventing water intoxication when compared with a whole extract of equal potency in maintaining life in the adrenalectomized dog. All substances used were, however, beneficial if adequate doses were given.