INEFFECTIVENESS OF COUMARIN TREATMENT ON THERMAL EDEMA OF MACROPHAGE-FREE RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (2) , 170-178
Abstract
The administration of silica prevents coumarin-stimulated lysis of accumulated abnormal protein. This impairs the resolution of thermal edema which is normally increased with coumarin administration. Apparently there is a rapid differentiation and infiltration of monocytes into the tissues and these are selectively retained. This is aided by coumarin which increases tissue permeability. Coumarin also injures the vascular endothelium of some vessels, allowing extra protein and fluid into the tissues. Death of recently differentiated macrophages and subsequent release of their lysosomal contents into the extracellular spaces may be responsible for the changes in serum enzyme levels. Macrophages probably are the only cells in which coumarin stimulates increased phagocytosis, enzyme production and proteolysis.