TREATMENT OF STEROID-DEPENDENT ASTHMA WITH TRIAMCINOLONE ACETONIDE AEROSOL

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (3) , 192-197
Abstract
Corticosteroids, originally developed as topical agents, have proved effective in aerosol form in the treatment of asthma. Of 33 chronic bronchial asthmatic patients dependent on oral corticosteroids, 16 were randomly selected for treatment with triamcinolone acetonide aerosol and 17 for treatment with placebo to determine the effectiveness of the active drug and the feasibility of eliminating or reducing oral steroids. Aerosol dosages of 800 g daily continued for 12 wk. The patients improved about 30, 50 and 60% in mean FVC [forced vital capacity], FEV1 [forced expiratory vol in 1 S], and FEF25 75 [forced expiratory flow over the mid-50% of the vital capacity], respectively. Their mean oral steroid dose dropped 77%, with 13 of the 16 discontinuing oral steroids entirely, and their asthma symptoms decreased about 30%. Placebo patients showed minimal or no improvement in these areas. The clinical results indicated that 14 of 16 active aerosol and 4 of 17 placebo aerosol patients improved over baseline. No side effects or fungal infections appeared and only 2 patients experienced oral-steroid withdrawal symptoms.

This publication has 0 references indexed in Scilit: