Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata.
Open Access
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (1) , 337-341
- https://doi.org/10.1128/mcb.6.1.337
Abstract
The insulin mRNA levels of rat insulinoma cell lines increased six- to eightfold, and the cells entered a transient state of growth arrest when they were cultured in serum-free, hormonally defined medium and on an extract of extracellular matrix derived from a basement membrane-secreting tumor line, EHS. Insulinoma cultures in growth arrest responded to glucose with a two- to threefold increase in insulin secretion associated with an insulin mRNA that contained a poly(A) tail that was 120 to 140 bases longer than normal.This publication has 27 references indexed in Scilit:
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