Frequency of Sickling Disorders in U.S. Blacks

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Abstract
THERE has been considerable recent interest in screening for sickling disorders and related hemoglobinopathies. It is recognized that the sickle-cell trait and the hemoglobin C trait are common among blacks in the United States (Table 1).1 β-thalassemia also occurs in this population (Table 1)1 but will not be discovered in many routine screening programs since detection requires special technics. Hereditary persistence of fetal hemoglobin is relatively uncommon (Table 1).1 The sickle-cell trait is very rarely associated with symptoms, and hemoglobin C trait is never clinically symptomatic. Counseling programs and screening programs will largely need to deal with healthy carriers of . . .

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