Synthesis of11C-labelled ketones via carbonylative coupling reactions using [11C]carbon monoxide
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 287-289
- https://doi.org/10.1039/p19950000287
Abstract
Ketones, labelled with 11C in the carbonyl position, were synthesised by the use of [11C]carbon monoxide in palladium-promoted carbonylative coupling reactions of organic halides with organotm reagents. 100–300 MBq of compounds 1–3were obtained within 30 min after the end of bombardment, starting from approximately 1000 MBq [11C]carbon monoxide, and the decay-corrected radiochemical yields were in the range 25–50% based on the [11C]carbon monoxide.Keywords
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