Human immunoglobulin variable region genes: A new VH sequence used to detect polymorphism
- 1 March 1987
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 25 (3) , 184-192
- https://doi.org/10.1007/bf00344033
Abstract
A human heavy chain variable region subgroup III pseudogene (HV3.3) was isolated, characterized, and sequenced. When HV3. was hybridized to Southern blots of human DNA, two potentially informative polymorphic bands, resulting from 2.7 kb Hind III (HH2.7) and 7.3 kb Eco RI(HE7.3) fragments, were detected with frequencies of 0.553 and 0.606, respectively. These polymorphic bands showed Mendelian segregation in families and appeared to be in tight linkage disequilibrium with each other (χ 1 2 =24.91, PV H gene repertoires in man.This publication has 41 references indexed in Scilit:
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