BIOCHEMICAL AND PHYSIOLOGICAL DIFFERENTIATION DURING MORPHOGENESIS. X. ONSET OF ELECTRICAL ACTIVITY IN DEVELOPING CEREBRAL CORTEX OF FETAL GUINEA PIG

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Abstract
Rhythmic potentials can first be recorded from the cortex of the fetal guinea pig at the 46th day of gestation (term 66 days), immediately following the period found to be critical for morphological and biochemical changes which are believed to accompany the differentiation of neuroblasts into neurones. Prompt production of strychnine spikes following local application of strychnine to the cortex provides evidence that the potentials are at least partly cortical in origin. The onset of cortical electrical activity is correlated temporally with evidence that can be interpreted to mean that the neurones of the cortex become permeable to Na at this time.