Effect of Ethanol on Formation of Hippuric Acid by the Liver

Publisher Website
Google Scholar
Abstract
Summary The effect of ethanol on the formation of hippuric acid was determined in studies on non-fasting human males without renal or hepatic disease after oral or intravenous administration of sodium benzoate and premedication with glycine by mouth. Ethanol, given orally or intravenously, resulted in significant decreases in urinary excretion of hippuric acid in all subjects tested. Each subject served as his own control. In similar studies, intravenous administration of sorbitol produced no significant changes in urinary excretion of hippuric acid. The results suggest that the hepatic processes that conjugate benzoate with glycine to form hippurate are impaired during oxidation of ethanol.