ACIDOPHILIC PITUITARY TUMORS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 100  (7) , 346-351
Abstract
The cells of pituitary adenomas classified as acidophilic on periodic acid Schiff-light green-orange G staining could be further differentiated with the Brookes technique: they stained nonspecifically bluish-gray, orange with orange G or red with carmolsine. On immunostaining for growth hormone and prolactin, the gray cells were either negative or reactive for prolactin, the orange cells contained growth hormone and the red cells contained prolactin. Of 28 tumors, 8 showed no immunostaining, 11 stained only for prolactin, 3 stained only for growth hormone, 5 contained mostly growth hormone cells and some prolactin cells, and 1 contained predominantly prolactin cells but also numerous growth hormone cells. Immunoreactive growth hormone granules in adenoma cells were usually arranged randomly; prolactin granules were often concentrated along one nuclear pole. The tinctorial and immunocytochemical heterogeneity of acidophilic adenomas was emphasized.

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