R gene expression induced by a type-III effector triggers disease resistance in rice
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- 23 June 2005
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 435 (7045) , 1122-1125
- https://doi.org/10.1038/nature03630
Abstract
Disease resistance (R) genes in plants encode products that specifically recognise incompatible pathogens and trigger a cascade of events leading to disease resistance in the host plant1. R-gene specificity is dictated by both host R genes and cognate avirulence (avr) genes in pathogens2,3. However, the basis of gene-for-gene specificity is not well understood. Here, we report the cloning of the R gene Xa27 from rice and the cognate avr gene avrXa27 from Xanthomonas oryzae pv. oryzae. Resistant and susceptible alleles of Xa27 encode identical proteins. However, expression of only the resistant allele occurs when a rice plant is challenged by bacteria harbouring avrXa27, whose product is a nuclear localized type-III effector. Induction of Xa27 occurs only in the immediate vicinity of infected tissue, whereas ectopic expression of Xa27 resulted in resistance to otherwise compatible strains of the pathogen. Thus Xa27 specificity towards incompatible pathogens involves the differential expression of the R gene in the presence of the AvrXa27 effector.Keywords
This publication has 28 references indexed in Scilit:
- The Rice Bacterial Blight Resistance Gene xa5 Encodes a Novel Form of Disease ResistanceMolecular Plant-Microbe Interactions®, 2004
- Plant disease resistance protein signaling: NBS–LRR proteins and their partnersPublished by Elsevier ,2004
- Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor kinase‐like proteinThe Plant Journal, 2004
- High-resolution genetic mapping of Xa27(t), a new bacterial blight resistance gene in rice, Oryza sativa L.Theoretical and Applied Genetics, 2003
- Understanding the Functions of Plant Disease Resistance ProteinsAnnual Review of Plant Biology, 2003
- Identifying type III effectors of plant pathogens and analyzing their interaction with plant cellsCurrent Opinion in Microbiology, 2003
- AvrXa10 Contains an Acidic Transcriptional Activation Domain in the Functionally Conserved C TerminusMolecular Plant-Microbe Interactions®, 1998
- Expression of Xa1 , a bacterial blight-resistance gene in rice, is induced by bacterial inoculationProceedings of the National Academy of Sciences, 1998
- A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21Science, 1995
- Current Status of the Gene-For-Gene ConceptAnnual Review of Phytopathology, 1971