Methylene-C 14 -Dioxyphenyl Compounds: Metabolism in Relation to Their Synergistic Action
- 2 September 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3740) , 1130-1133
- https://doi.org/10.1126/science.153.3740.1130
Abstract
The methylene-C14 group is hydroxylated yielding formate-C14 in the microsome-reduced nicotinamide-adenine dinucleotide phosphate system in vitro and yielding expired C14O2, in living mice and houseflies. Methylenedioxyphenyl compounds apparently serve as alternate substrates for this enzymatic hydroxylation system of microsomes, and thus reduce the rate of metabolism and prolong the action of certain drugs and insecticide chemicals.This publication has 29 references indexed in Scilit:
- Metabolism of Methylcarbamate Insecticides by the NADPH2-requiring Enzyme System from HousefliesNature, 1967
- Microsomal epoxidation of cyclodiene insecticidesBiochemical Pharmacology, 1965
- Carcinogenic Potential of PesticidesArchives of environmental health, 1965
- Kinetics of drug metabolism by hepatic microsomesBiochemical Pharmacology, 1964
- The effect of pyrethrin synergists, especially sesamex, on the insecticidal potency of hexachlorocyclopentadiene derivatives (“cyclodiene” insecticides) in the adult housefly, Musca Domestica LBiochemical Pharmacology, 1964
- Mode of Action of CarbamatesAnnual Review of Entomology, 1963
- Activation of organophosphorus insecticides by rat liver microsomesToxicology and Applied Pharmacology, 1962
- THE PREPARATION OF P-BROMOPHENACYL ESTERS AND THE CHARACTERIZATION OF P-BROMOPHENACYL FORMATECanadian Journal of Chemistry, 1952
- On PhenyletheraseExperimental Biology and Medicine, 1947
- Zur Pharmakologie des Apiols und einiger seiner VerwandtenNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1927