SENSITIZATION BY INSULIN TO THE DEXTRAN "ANAPHYLACTOID" REACTION
- 1 April 1957
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 35 (4) , 251-256
- https://doi.org/10.1139/o57-032
Abstract
A single subcutaneous injection of crystalline insulin (20 units) sensitizes considerably the rats to the dextran "anaphylactoid" reaction. This is a type of acute serous inflammation. Insulin precipitates the reaction after a very small dose of dextran (0.05-0.01 ml., 6% solution) has been injected into a "shock organ". Without insulin, such small doses of dextran are quite ineffective. Insulin also precipitates the reaction when dextran (1.0 ml., 6% solution) is injected peripherally on the back. In this site and at this dose, it rarely produces the reaction in normal rats. The sensitization manifests itself despite a cortisone pretreatment.Keywords
This publication has 3 references indexed in Scilit:
- ANTIPHLOGISTIC EFFECT OF TRYPSIN IN NORMAL AND IN ADRENALECTOMIZED RATSCanadian Journal of Biochemistry and Physiology, 1955
- Influence of inoculation site upon the course of the “anaphylactoid reaction” to dextranJournal of Allergy, 1954
- STUDIES ON ADAPTATIONEndocrinology, 1937