Abstract
A case illustrating Mohs micrographic surgery fixed‐tissue technique in the treatment of a large basal cell carcinoma of the left nasal alar groove in a patient with acquired immunodeficiency syndrome is described. Fixation of the tissue before excision and appropriate infectious disease precautions minimize exposure to the human immunodeficiency virus by the surgical and laboratory personnel, while Mohs micrographic mapping assures complete removal of a potentially life‐threatening cancer in an immunocompromised patient.