INFLUENCE OF AMINOPHYLLINE OR BETA-ADRENOCEPTOR BLOCKADE ON GLUCAGON-RELEASE BY A VASOACTIVE ADENOSINE ANALOG

  • 1 January 1978
    • journal article
    • research article
    • Vol. 234  (2) , 214-220
Abstract
The glucagon-releasing activity of adenosine-5''-ethyl-carboxamide (744-96) was studied in conscious dogs pretreated either with aminophylline or with bupranolol, a .beta.-adrenoceptor blocking drug. The adenosine antagonist, aminophylline, inhibited both the glucagon-releasing and the blood pressure lowering effects of 744-96 (10 .mu.g/kg i.v.). The actions of the adenosine analog on glucagon release and hemodynamics were not affected by bupranolol pretreatment. The adenosine analog mediates glucagon release by interaction with so-called adenosine receptors. A .beta.-adrenoceptor mediated release secondary to 744-96-induced hypotension and baroreceptor-activation can be excluded.

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