OBSERVATIONS ON CERTAIN MANIFESTATIONS OF CIRCULATORY CONGESTION PRODUCED IN DOGS BY RAPID INFUSION

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Abstract
Rapid infusion in dogs produced: congestion in the peripheral, pulmonary, and portal venous systems, evidenced by rises in their venous pressures, swelling of the abdomen, liver and spleen and, in some cases, pulmonary edema; an increase in plasma volume and a dilution of the serum proteins; an increase in the heart rate, heart size, and cardiac output accompanied by a gallop rhythm and systolic murmur; and an increase in O2 consumption. These phenomena and their relationship to congestive failure in humans are discussed. An explanation is offered for the stabilization of the peripheral venous pressure, which takes place during infusion.