THE PRESSOR EFFECTS OF HOMOLOGOUS AND HETEROLOGOUS INJECTIONS OF HEATED KIDNEY EXTRACTS

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Abstract
Rapidly repeated injs. of heated kidney extracts into intact animals with or without anesthesia lead to a diminished response (tachyphylaxis). Rabbits receiving rabbit kidney extracts at intervals ranging from 24 hrs. to 7 or 10 days exhibit no significant change of resting blood pressure or conspicuous change of sensitivity to renin. When rabbits have received an inj. of similarly prepared extract from another sp., subsequent inj. of that extract, after a suitable interval, produces respiratory-distress, a sharp drop in blood pressure, blanching of the ear, arteriolar constriction in the ear, and death if the inj. is not stopped immediately. The general picture is that of anaphylactic shock. Potent kidney extracts raise blood pressure in the sp. of origin and in other spp. as well. Extracts of normal rabbits'' kidneys are most actively pressor, those from rats and guinea pigs somewhat less active, and those from man and dog least active, when prepared by heating to 55[degree]C. for 20 mins. The reactivity of these spp. varies, however, in that with a given group of extracts, the rat and guinea pig show more conspicuous elevation of blood pressure than do the dog and rabbit after inj. of equivalent doses.

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