LYSOZYME ENHANCEMENT OF TUMOR-CELL IMMUNOPROTECTION IN A MURINE FIBRO-SARCOMA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (5) , 1642-1645
Abstract
The ability of human lysozyme (HLZM) to enhance the immunogenicity of a methylcholanthrene-induced murine fibrosarcoma in C57BL/10 mice was studied. Following s.c. injection of 104 live tumor cells, 100% of the mice developed palpable tumors within 16 .+-. 3 (SD) days. Prechallenge immunization with 106 irradiated tumor cells with or without complete Freund''s adjuvant resulted in protection from tumor development in 14 and 22% of the mice, respectively. Incubation of tumor cells with HLZM prior to immunization approximately doubled the degree of protection, with 42-44% of the mice remaining free of tumor. This enhanced protection was dependent on the enzymatic activity of HLZM. HLZM probably enhances tumor cell immunogenicity in this model.