CYCLOSPORINE AND SKIN ALLOGRAFTS FOR THE TREATMENT OF THERMAL INJURY

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Abstract
We have previously reported the successful treatment and apparent development of skin allograft tolerance in a patient sustaining massive burns, utlilizing skin allografts and cyslosporine. We now report the experimental correlate via successful achievement of a 75% body surface area (BSA) scald burn cyclosporine - skin allograft model in Lewis (LEW) rats. Cyclosporine (8 mg/kg/day) was given to the experimental animals daily for the first 20 days and then three times a week thereafter. Two experimental groups were studied: one received standard posttrauma care and the second critical post-trauma care. Controls (n = 22) and experimental groups 1 (n = 28) and 2 (n = 4) had average survival times of 13.8 .+-. 12.8 days, 44.2 .+-. 132.5 days, and 172.0 .+-. 19.4 days, respectively. The allografts on the surviving experimental animals appeared normal and healthy and had nearly perfect hair growth. These results indicate that the model follows the clinical burn wound course, and treatment of massive burns with primary excision, skin allografts, and low doses of cyclosporine could provide immediate and complete functional repair of the burn wound.