THE EFFECT OF AMINOPHYLLINE ON THE BLOOD VOLUME OF THE BRAIN OF THE WHITE RAT

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Abstract
White rats treated with either comparable clinical doses (3.20mg/kg or massive doses (225 mg/kg) of aminophylline, were injected with radio-iodinated serum albumin in an attempt to determine whether aminophylline alters the size of the vascular pool of the brain. These experiments were performed to determine the effects of aminophylline on the blood volume of the brain of the white rat. Both failed to alter the size of vascular space of the rat central nervous system, although the larger dose did have a marked vasoconstrictory effect upon the gastrocnemius muscle. The observations reported in this study neither refute nor support the observations of other investigators using different species and experimental models. The failure to observe specific changes in blood volume in the rat central nervous system in no way suggests that changes do or do not occur in other species, or in the rat under different experimental conditions.