STUDIES ON HUMAN PRELEUKEMIA .4. CLINICAL AND PROGNOSTIC SIGNIFICANCE OF SIDEROBLASTS IN A REGENERATIVE ANEMIA WITH HYPER-CELLULAR BONE-MARROW

  • 1 January 1978
    • journal article
    • research article
    • Vol. 21  (5) , 396-402
Abstract
The prognostic significance of the bone marrow sideroblasts found in aregenerative anemia with hypercellular bone marrow was evaluated particularly to see if the sideroblasts might be a preleukemic sign. The study included 32 patients with abnormal sideroblasts; 14 had mainly ringed sideroblasts while 18 had mainly the intermediate or ferritin type. Basic erythrokinetic data (59Fe erythrocyte incorporation and erythroblast labeling indices) were similar in the 2 groups. The colony forming capacity (CFUc) was abnormal in 2 of 5 patients with ringed sideroblasts compared to 12 of 13 in the intermediate sideroblast group. Patients with mainly ringed sideroblasts had significantly longer duration of disease state, higher platelet and leukocyte counts, no increase in the percentage of bone marrow myeloblasts and less often developed acute leukemia. Thus aregenerative anemias can be divided according to the type of abnormal sideroblasts in 2 groups with different risk of development of acute leukemia. The ringed sideroblastic anemia seems not to be a preleukemic stage in the prospective sense in contrast to aregenerative anemia with mainly intermediate sideroblasts.

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