THE EFFECT OF CORTISONE ACETATE ON THE PRODUCTION OF CIRCULATING HEMOLYTIC ANTIBODIES IN THE MOUSE
- 1 July 1954
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 32 (4) , 372-382
- https://doi.org/10.1139/o54-040
Abstract
Quantitative immuno-chemical methods were used to show that in the mouse cortisone acetate suppresses the formation of circulating hemolytic anti-bodies to sheep erythrocytes. The amt. of suppression varies with the dose of both cortisone acetate and antigen. Exptl. conditions are defined whereby an almost complete inhibition of circulating antibody occurs. The method serves as a quantitative procedure for comparing the effect of different steroids and hormones on antibody production as well as a means of studying possible cortisone antagonists.Keywords
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