Mutagenicity of resin acids identified in pulp and paper mill effluents using the salmonella/mammalian‐microsome assay
- 1 January 1979
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 1 (4) , 361-369
- https://doi.org/10.1002/em.2860010408
Abstract
Ten resin acids which have been identified as constituents of pulp and paper mill effluents have been examined for potential mutagenicity in the Salmonella/mammalian‐microsome assay. Only neoabietic acid has been found to be mutagenic. Neoabietic acid showed dose‐related increases in mutagenicity in strains TA1535, TA100, TA1538, and TA98, but not in strain TA1537. Metabolic activation with a preparation of Aroclor 1254‐induced liver homogenate (S9) slightly reduced the mutagenic responses. Negative responses were found for abietic acid, dehydroabietic acid, levopimaric acid, 7‐oxodehydroabietic acid, monochlorodehydroabietic acid, dichlorodehydroabietic acid, pimaric acid, isopimaric acid, and sandaracopimaric acid.Keywords
This publication has 16 references indexed in Scilit:
- The relationship between mutagenicity and carcinogenicity of some nitrosaminesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- The relationship between carcinogenicity and mutagenicity of some polynuclear hydrocarbonsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Distribution of Dehydroabietic Acid in Sediments Adjacent to a Kraft Pulp and Paper MillJournal of the Fisheries Research Board of Canada, 1977
- Persistence of Dissolved Organic Compounds in Kraft Pulp and Paper Mill Effluent PlumesJournal of the Fisheries Research Board of Canada, 1977
- The toxicity of pulp and paper mill effluents and corresponding measurement proceduresWater Research, 1976
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.Proceedings of the National Academy of Sciences, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Isolation and Identification of Constituents Toxic to Juvenile Rainbow Trout (Salmo gairdneri) in Caustic Extraction Effluents from Kraft Pulpmill Bleach PlantsJournal of the Fisheries Research Board of Canada, 1975
- Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for DetectionProceedings of the National Academy of Sciences, 1973
- An Improved Procedure for the Isolation of Neoabietic Acid From Pine Oleoresin and RosinThe Journal of Organic Chemistry, 1956