Effect of Diet and Minerals on Recovery of “Insulin Activity” in Serum

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Abstract
Using an adipose tissue assay, “insulin activity” was fully recovered upon addition to normal rat sera. If rats were fed a diet containing Torula yeast as the source of protein, “insulin activity” added to such sera was only partially recovered. Serum does not normally contain an insulin-degrading system. Feeding of the Torula diet is known to produce a chromium deficiency which is characterized by a delayed glucose disappearance rate, but the addition of chromium salts to the diet did not restore recovery of “insulin activity” to normal. However, if the Torula diet was supplemented with an additional 1 % cystine, complete recovery of “insulin activity” added to the sera of such rats was observed. (Endocrinology75: 752, 1964)