THE AGGLUTINATION OF FISH ERYTHROCYTES BY NORMAL HUMAN SERA

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Abstract
1. Normal human sera were found to agglutinate the erythrocytes of the shiner sea-perch (Cymatogaster aggregata) and of the kingfish (Genyonemus lineatus). 2. Agglutination was shown to occur by virtue of four different antigens, each species having two of these four in its erythrocytes. 3. Of these, Genyonemus had an antigen with a specificity closely resembling the human B substance (designated here as F-1) and a species-specific antigen (F-2) peculiar to itself. 4. Cymatogaster had a species-specific antigen (F-3) and an antigen with a specificity resembling that of the Forssman antigen (F-4). 5. No individual variations were found in either fish with respect to these antigens.