The Nazarov Cyclisation

Abstract
The thermal conrotatory ring closure of divinyl ketones in acidic medium leads to cyclopentenones with excellent yields. This reaction represents one of the best methods for cyclopentenone annelation. The synthesis of the divinyl ketone precursors and cyclisation conditions are summarised in this review. 1. Introduction 2. Cyclisation of 1,5-Dien-3-ynes 3. Ring Closure of Allyl Vinyl Ketones and Divinyl Ketones 4. Ring Closure of Acetylenic Diols 5. Cyclopentenones from Friedel-Crafts Acylation 6. Photochemical Ring Closure of Divinyl Ketones 7. Related Reactions 8. Applications to the Synthesis of Natural Products

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