Thyroglobulin-Like Substances in Human Thyroid Subcellular Particulates

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Abstract
Summary Human thyroid subcellular fractions, mitochondrial and microsomal, and soluble thyroglobulin were separated from thyroid glands and injected into rabbits. Rabbit antisera obtained were tested for antibodies against thyroglobulin. By hemmagglutination tests, antisera directed against thyroid subcellular particulates showed high titers against thyroglobulin. Immunodiffusion and immunoelectrophoresis experiments with thyroid subcellular particulates revealed the presence of several antigenic components; one was identical with thyroglobulin and one or two others were similar to, but antigenically deficient as compared to thyroglobulin. These thyroglobulin-like substances were bound to subcellular particulates, but dissociable upon the treatment with deoxycholate.

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