Cordycepin Inhibition of 3-Methylcholanthrene-Induced Transformation In Vitro

1 December 1975

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 150 (3) , 650-653
https://doi.org/10.3181/00379727-150-39098

Abstract

Cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, inhibited the induction of the endogenous type "C" RNA virus by 5-iodo-2''-deoxyuridine in a line of Fischer rat embryo cells (H43) grown in vitro. When continuously incorporated into the medium at those same concentrations, it protected the cells from transformation by the chemical carcinogen 3-methylcholanthrene.