CORTISONE IN SYDENHAM'S CHOREA

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Abstract
Beneficial effects of cortisone and pituitary adrenocorticotropic hormone (ACTH) on acute manifestations of rheumatic fever have recently been described.1 In particular, the effects on rheumatic polyarthritis and carditis have been studied. Since acute chorea is generally believed to be another manifestation of rheumatic fever,2 we considered it of interest to determine the effects of cortisone in two cases of chorea that have recently come under our observation. To one of the patients pituitary adrenocorticotropic hormone was also administered. REPORT OF CASES Case 1.— J. S., a 3 year old boy, was admitted to Beth Israel Hospital on June 18, 1950. Four weeks previously he had experienced a gradual onset of weakness of both arms and legs, associated with uncontrollable, purposeless movements of his limbs and face. Difficulty in swallowing and in speaking followed, and the patient was unable to sit or stand without support. Two weeks prior to

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