Effects of Preweaning Undernutrition and Continued Postweaning Protein Deficiency or Nutritional Rehabilitation on Polyphosphoinositides in Rat Brain

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Abstract
Metabolically inert polyphosphoinositides seem to play an important role in the structural development of neurons, glia and myelin. The metabolically active pool of PhIpp [phosphatidyl inositol 4''5''-phosphate] appears to be important for the functional development of glia and myelin during the postweaning period, whereas PhIp [phosphatidyl inositol 4''-phosphate] seems to be more important for the functional development of neurons during the preweaning period. Neonatal undernutrition reduces the concentrations of structural polyphosphoinositides and metabolic PhIp while metabolic PhIpp remains unaltered. These effects can be reversed by postweaning nutritional rehabilitation. A continued postweaning protein deficiency of neonatally undernourished rats effects structural PhIpp more than PhIp. Metabolically active PhIpp is drastically reduced.