Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain
- 1 January 1988
- journal article
- conference paper
- Published by Springer Nature in Neurochemical Research
- Vol. 13 (1) , 69-75
- https://doi.org/10.1007/bf00971857
Abstract
The objective of the present study was to compare the effects of elevation of GABA concentration and those of inactivation ofl-ornithine: 2-oxoacid aminotransferase (OAT) on the in vivo metabolism ofl-ornithine (Orn) in brain. Vigabatrin (4-aminohex-5-enoic acid) and gabaculine (5-amino-1,3-cyclohexadienyl carboxylic acid), two well known inactivators of GABA-T, were used to elevate brain GABA concentrations. The latter inactivates OAT also. Transamination of Orn is, from a quantitative point of view, a significant reaction in mouse brain. GABA is a feed-back regulator of OAT. Within GABAergic neurons Orn concentration may be regulated by endogenous GABA. Extensive inactivation of OAT causes a considerable increase of Orn concentration, both in synaptosomes and in non-synaptosomal compartments. The results are compatible with a role of Orn as precursor of glutamate and/or GABA in certain neurons.This publication has 31 references indexed in Scilit:
- Interrelationships between ornithine, glutamate and GABA—I. Feed-back inhibition of ornithine aminotransferase by elevated brain GABA levelsNeurochemistry International, 1987
- Ornithine as a precursor of glutamate and GABA: Uptake and metabolism by neuronal and glial enriched cellular materialJournal of Neuroscience Research, 1983
- Developmental changes in mouse brain polyamine metabolismNeurochemical Research, 1982
- A New Synaptosomal Biosynthetic Pathway of Glutamate and GABA from Ornithine and Its Negative Feedback Inhibition by GABAJournal of Neurochemistry, 1982
- A Sensitive Radiometric Assay for Ornithine Aminotransferase: Regional and Subcellular Distributions in Rat BrainJournal of Neurochemistry, 1981
- Relationships between GABA and polyamines in developing rat brainNeuropharmacology, 1980
- The biological and biochemical properties of L-canaline, a naturally occurring structural analogue of L-ornithineLife Sciences, 1978
- γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE1Journal of Neurochemistry, 1977
- The in vivo inhibition of gaba-transaminase by gabaculineBiochemical and Biophysical Research Communications, 1977
- 4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian BrainEuropean Journal of Biochemistry, 1977