Ingested Arsenic, Keratoses, and Bladder Cancer
- 15 August 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 136 (4) , 417-421
- https://doi.org/10.1093/oxfordjournals.aje.a116514
Abstract
A cohort of 478 patients treated with Fowler's solution (potassium arsenite) in Lancashire, England, during the penod 1945–1969 and previously followed until January 1, 1980, was followed for an additional 11 years. A significant excess of bladder cancer mortality occurred (observed/expected ratio = 5/1.6; p = 0.05). No excess was found for other causes of death. In a subcohort of 142 patients examined for signs of arsenicism around 1970, all 11 subsequent cancer deaths occurred in those with signs of arsenicism (p = 0.0009).Keywords
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