NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions
Top Cited Papers
Open Access
- 1 July 2002
- journal article
- review article
- Published by American Society for Microbiology in Clinical Microbiology Reviews
- Vol. 15 (3) , 414-429
- https://doi.org/10.1128/cmr.15.3.414-429.2002
Abstract
Transcription factors of the Rel/NF-κB family are activated in response to signals that lead to cell growth, differentiation, and apoptosis, and these proteins are critical elements involved in the regulation of immune responses. The conservation of this family of transcription factors in many phyla and their association with antimicrobial responses indicate their central role in the regulation of innate immunity. This is illustrated by the association of homologues of NF-κB, and their regulatory proteins, with resistance to infection in insects and plants (M. S. Dushay, B. Asling, and D. Hultmark, Proc. Natl. Acad. Sci. USA 93:10343-10347, 1996; D. Hultmark, Trends Genet. 9:178-183, 1993; J. Ryals et al., Plant Cell 9:425-439, 1997). The aim of this review is to provide a background on the biology of NF-κB and to highlight areas of the innate and adaptive immune response in which these transcription factors have a key regulatory function and to review what is currently known about their roles in resistance to infection, the host-pathogen interaction, and development of human disease.Keywords
This publication has 235 references indexed in Scilit:
- PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytesNature, 2000
- Influenza Virus-induced NF-κB-dependent Gene Expression Is Mediated by Overexpression of Viral Proteins and Involves Oxidative Radicals and Activation of IκB KinaseJournal of Biological Chemistry, 2000
- Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell Accessory Molecule CD28Journal of Biological Chemistry, 1998
- CD40 AND CD154 IN CELL-MEDIATED IMMUNITYAnnual Review of Immunology, 1998
- Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune ResponsesThe Journal of Experimental Medicine, 1998
- Requirement for NF-κB in osteoclast and B-cell developmentGenes & Development, 1997
- Neisseria gonorrhoeae Epithelial Cell Interaction Leads to the Activation of the Transcription Factors Nuclear Factor κB and Activator Protein 1 and the Induction of Inflammatory CytokinesThe Journal of Experimental Medicine, 1997
- p50–NF-κB Complexes Partially Compensate for the Absence of RelB: Severely Increased Pathology in p50−/−relB−/−Double-knockout MiceThe Journal of Experimental Medicine, 1997
- Immunological defects in mice with a targeted disruption in Bcl-3.Genes & Development, 1997
- Signals from the IL-1 Receptor Homolog, Toll, Can Activate an Immune Response in a Drosophila Hemocyte Cell LineBiochemical and Biophysical Research Communications, 1995