Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin

1 January 2001

journal article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 14,p. 1252-1253
https://doi.org/10.1039/b103668h

Abstract

The biosynthetic pathway to the L-di-meta-hydroxyphenylglycine (DHPG) constituent of chloroeremomycin (A82846B), has been investigated by a combination of feeding experiments with¹³C-labelled substrates, and expression and assay of HpgT from the chloroeremomycin biosynthetic cluster.

Keywords

DI META
CONSTITUENT
HYDROXYPHENYLGLYCINE
13C
VANCOMYCIN
A82846B
FEEDING
SUBSTRATES
HPGT

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