Experimental Inoculation of Chickens with Hodgkin's Nodes

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Abstract
Five healthy chickens were inoculated intravenously with emulsions of lymph nodes from 2 cases of clinically and histologically characteristic Hodgkin's disease. All of these chickens developed either a typical or an atypical tuberculosis and in the tissue smears, stained by Ziehl-Neilsen method, acid-fast granules and rods, extra- and intracellular, were demonstrated in two of them, and non-acid-fast granules in one of them. Reinoculation of material from the lesions of one of these chickens into another chicken produced an identical though more extensive manifestation of the disease. An atypical tuberculosis developed in a guinea pig by inoculation of the tissue from the fourth chicken. A pure growth of bacteria with the staining and cultural characteristics of the avian tubercle bacillus was produced on egg media from material from this guinea pig. Cultures from these birds on egg media were contaminated in all instances. In one there was a symbiotic growth of a blastomyces-like organism with an acid-fast bacillus.

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